Selective enhancement of rapid eye movement sleep by deep brain stimulation of the human pons
Identifieur interne : 001E92 ( Main/Exploration ); précédent : 001E91; suivant : 001E93Selective enhancement of rapid eye movement sleep by deep brain stimulation of the human pons
Auteurs : Andrew S. Lim [Canada, États-Unis] ; Elena Moro [Canada] ; Andres M. Lozano [Canada] ; Clement Hamani [Canada] ; Jonathan O. Dostrovsky [Canada] ; William D. Hutchison [Canada] ; Anthony E. Lang [Canada] ; Richard A. Wennberg [Canada] ; Brian J. Murray [Canada]Source :
- [ 0364-5134 ]
English descriptors
- KwdEn :
- Aged, Deep Brain Stimulation (methods), Female, Humans, Male, Middle Aged, Parkinson Disease (complications), Parkinson Disease (therapy), Polysomnography (methods), Pons (physiology), REM Sleep Behavior Disorder (etiology), REM Sleep Behavior Disorder (therapy), Supranuclear Palsy, Progressive (complications), Supranuclear Palsy, Progressive (therapy).
- MESH :
- complications : Parkinson Disease, Supranuclear Palsy, Progressive.
- etiology : REM Sleep Behavior Disorder.
- methods : Deep Brain Stimulation, Polysomnography.
- physiology : Pons.
- therapy : Parkinson Disease, REM Sleep Behavior Disorder, Supranuclear Palsy, Progressive.
- Aged, Female, Humans, Male, Middle Aged.
Abstract
Animal studies suggest that rapid eye movement (REM) sleep is governed by the interaction of REM‐promoting and REM‐inhibiting nuclei in the pontomesencephalic tegmentum. The pedunculopontine nucleus is proposed to be REM promoting. Using polysomnography, we studied sleep in five parkinsonian patients undergoing unilateral pedunculopontine nucleus deep brain stimulation (DBS). We demonstrated a near doubling of nocturnal REM sleep between the DBS “off” and DBS “on” states, without significant changes in other sleep states. This represents the first demonstration that DBS can selectively modulate human sleep, and it supports an important role for the pedunculopontine nucleus region in modulating human REM sleep. Ann Neurol 2009;66:110–114
Url:
DOI: 10.1002/ana.21631
Affiliations:
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Lozano</name><affiliation wicri:level="1"><country xml:lang="fr">Canada</country><wicri:regionArea>Division of Neurosurgery, Department of Surgery, Toronto, Ontario</wicri:regionArea><wicri:noRegion>Ontario</wicri:noRegion></affiliation></author><author><name sortKey="Hamani, Clement" sort="Hamani, Clement" uniqKey="Hamani C" first="Clement" last="Hamani">Clement Hamani</name><affiliation wicri:level="1"><country xml:lang="fr">Canada</country><wicri:regionArea>Division of Neurosurgery, Department of Surgery, Toronto, Ontario</wicri:regionArea><wicri:noRegion>Ontario</wicri:noRegion></affiliation></author><author><name sortKey="Dostrovsky, Jonathan O" sort="Dostrovsky, Jonathan O" uniqKey="Dostrovsky J" first="Jonathan O." last="Dostrovsky">Jonathan O. Dostrovsky</name><affiliation wicri:level="4"><country xml:lang="fr">Canada</country><wicri:regionArea>Department of Physiology, University of Toronto, Toronto, Ontario</wicri:regionArea><orgName type="university">Université de Toronto</orgName><placeName><settlement type="city">Toronto</settlement><region type="state">Ontario</region></placeName></affiliation></author><author><name sortKey="Hutchison, William D" sort="Hutchison, William D" uniqKey="Hutchison W" first="William D." last="Hutchison">William D. 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The pedunculopontine nucleus is proposed to be REM promoting. Using polysomnography, we studied sleep in five parkinsonian patients undergoing unilateral pedunculopontine nucleus deep brain stimulation (DBS). We demonstrated a near doubling of nocturnal REM sleep between the DBS “off” and DBS “on” states, without significant changes in other sleep states. This represents the first demonstration that DBS can selectively modulate human sleep, and it supports an important role for the pedunculopontine nucleus region in modulating human REM sleep. Ann Neurol 2009;66:110–114</div></front></TEI><affiliations><list><country><li>Canada</li><li>États-Unis</li></country><region><li>Massachusetts</li><li>Ontario</li></region><settlement><li>Toronto</li></settlement><orgName><li>Université de Toronto</li></orgName></list><tree><country name="Canada"><region name="Ontario"><name sortKey="Lim, Andrew S" sort="Lim, Andrew S" uniqKey="Lim A" first="Andrew S." last="Lim">Andrew S. Lim</name></region><name sortKey="Dostrovsky, Jonathan O" sort="Dostrovsky, Jonathan O" uniqKey="Dostrovsky J" first="Jonathan O." last="Dostrovsky">Jonathan O. Dostrovsky</name><name sortKey="Hamani, Clement" sort="Hamani, Clement" uniqKey="Hamani C" first="Clement" last="Hamani">Clement Hamani</name><name sortKey="Hutchison, William D" sort="Hutchison, William D" uniqKey="Hutchison W" first="William D." last="Hutchison">William D. Hutchison</name><name sortKey="Hutchison, William D" sort="Hutchison, William D" uniqKey="Hutchison W" first="William D." last="Hutchison">William D. Hutchison</name><name sortKey="Lang, Anthony E" sort="Lang, Anthony E" uniqKey="Lang A" first="Anthony E." last="Lang">Anthony E. Lang</name><name sortKey="Lozano, Andres M" sort="Lozano, Andres M" uniqKey="Lozano A" first="Andres M." last="Lozano">Andres M. Lozano</name><name sortKey="Moro, Elena" sort="Moro, Elena" uniqKey="Moro E" first="Elena" last="Moro">Elena Moro</name><name sortKey="Murray, Brian J" sort="Murray, Brian J" uniqKey="Murray B" first="Brian J." last="Murray">Brian J. Murray</name><name sortKey="Murray, Brian J" sort="Murray, Brian J" uniqKey="Murray B" first="Brian J." last="Murray">Brian J. Murray</name><name sortKey="Wennberg, Richard A" sort="Wennberg, Richard A" uniqKey="Wennberg R" first="Richard A." last="Wennberg">Richard A. Wennberg</name></country><country name="États-Unis"><region name="Massachusetts"><name sortKey="Lim, Andrew S" sort="Lim, Andrew S" uniqKey="Lim A" first="Andrew S." last="Lim">Andrew S. Lim</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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